Xiaochen Bo

NASTRA is a reference-free tool for STR genotyping using nanopore sequencing, achieving 100% accuracy in diploid STR analysis across multiple platforms.

EnrichMiner provides a web server to help researchers explore and refine functional enrichment analysis results by removing redundancy and selecting representative terms.

The paper introduces BiFC-seq, a yeast-based method for genome-wide interactome mapping, and demonstrates its application to Ebola virus and p53 interactomes, identifying known and novel interactions.

This paper predicts synthetic lethal gene pairs using a similarity fusion approach with k-NN classification, showing effectiveness and practicality.

HIT-scISOseq improves single-cell isoform sequencing throughput and accuracy, revealing novel transcriptomic features in corneal epithelium injury.

DeepHiC enhances Hi-C data resolution using a generative adversarial network, improving chromatin loop and TAD detection accuracy from low-coverage sequencing data.

The paper identifies and analyzes A-to-I RNA editing events in radiation-induced malignantly transformed cells, finding that SNPs affect ADAR2 activity and contribute to cancer progression.

The paper models the time-resolved succession of epigenetic regulation during early mammalian development and identifies key epigenetic events that coordinate transcriptional programs at different stages.

The paper identifies and characterizes HOT regions across human cell types, showing their association with developmental genes and unique epigenetic features.

PEDLA uses deep learning to predict enhancers from heterogeneous data, achieving high accuracy across multiple cell types.