Hao Hong

This paper presents a high-quality cattle genome assembly with improved continuity and completeness, revealing the highest known immune gene diversity in mammals.

DeepHiC enhances Hi-C data resolution using a generative adversarial network, improving chromatin loop and TAD detection accuracy from low-coverage sequencing data.

The paper models the time-resolved succession of epigenetic regulation during early mammalian development and identifies key epigenetic events that coordinate transcriptional programs at different stages.

This study integrates multiple analyses to characterize human essential genes and develops a web platform for their comprehensive interpretation.