New insights on human essential genes based on integrated analysis

Abstract

Essential genes are those whose functions govern critical processes that sustain life in the organism. Recent gene-editing technologies have provided new opportunities to characterize essential genes. Here, we present an integrated analysis for comprehensively and systematically elucidating the genetic and regulatory characteristics of human essential genes. First, essential genes act as \"hubs\" in protein-protein interactions networks, in chromatin structure, and in epigenetic modifications, thus are essential for cell growth. Second, essential genes represent the conserved biological processes across species although gene essentiality changes itself. Third, essential genes are import for cell development due to its discriminate transcription activity in both embryo development and oncogenesis. In addition, we develop an interactive web server, the Human Essential Genes Interactive Analysis Platform (HEGIAP) (http://sysomics.com/HEGIAP/), which integrates abundant analytical tools to give a global, multidimensional interpretation of gene essentiality. Our study provides a new view for understanding human essential genes.