Chih‐Lin Hsieh

The paper analyzes simple deletions in single human colon crypts across age, finding most are due to strand slippage and NHEJ, with age-related accumulation and radiation effects.

The paper analyzes mutation counts and profiles in single human colon crypts to assess somatic mutation rates and their implications for aging and disease.

This paper evaluates complex indel detection methods, finding FreeBayes best represents simulated complex indels as single variant records and develops a parsing workflow to extract complex indels from VCF output.

The paper identifies complex indels and NHEJ repair in human colon crypt stem cells using whole-genome sequencing to study DNA damage repair in a physiologically relevant context.

This study uses high-depth whole genome sequencing of single colon crypts to show they are often polyclonal, revealing cell-to-cell heterogeneity previously unattainable with lower sensitivity methods.

The paper analyzes naturally occurring somatic insertions in the human genome using whole-genome sequencing, finding replication slippage as a dominant mechanism for these events.