Laura Broglia

PHANES provides a comprehensive, interpretable database of protein features for the human proteome, integrating sequence, structure, and expression data to support biological analysis and machine learning.

The paper describes a synthetic circRNA-derived IRES-like element, SynFarsa, that enhances translation of an endogenous protein, HSP90, in trans by targeting its 3'UTR.

The paper maps RNA-DNA interactions in 16 human cell types, showing cell-type-specific and dynamic networks that correlate with gene regulation and disease traits.

The paper develops a computational framework to analyze IRES function by combining mutagenesis and RNA-protein interaction profiling, revealing structural and protein dependency differences between viral and cellular IRESs.

This paper designs aptamers targeting RAD51-BRCA2 interaction to inhibit RAD51 nuclear recruitment, enhancing DNA damage and cytotoxicity in pancreatic cancer cells.

The paper investigates how RNA modifications affect protein-RNA interactions and introduces an algorithm to predict these effects.

This study identifies SINEUP RNAs with Internal Ribosomal Entry Site (IRES) sequences as effector domains, enhancing translation of target mRNAs through both linear and circular transcripts.

PRALINE is a database that catalogs proteins and RNAs in biological condensates, their interactions, and the impact of single-nucleotide variants on condensate properties.