Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment
Giulia Milordini, Elsa Zacco, Alexandros Armaos, Francesco Di Palma, Mirco Masi, Martina Gilodi, Jakob Rupert, Laura Broglia, Giulia Varignani, Michele Oneto, Marco Scotto, Roberto Marotta, Stefania Girotto, Andrea Cavalli, Gian Gaetano Tartaglia
This paper designs aptamers targeting RAD51-BRCA2 interaction to inhibit RAD51 nuclear recruitment, enhancing DNA damage and cytotoxicity in pancreatic cancer cells.
bioRxiv · Jan 20, 2025 · PreprintBiochemistry