Elsa Zacco

The paper shows that amygdala TDP-43 pathology correlates with behavioural dysfunction and ferritin accumulation in sporadic ALS.

This study identifies RNA-binding activity of the SACSIN HEPN domain as linked to ARSACS, providing insights into its molecular function and potential therapeutic targets.

This study shows RNA binding alters the structure, function, and stability of alpha-synuclein fibrils, suggesting RNA as an active co-factor in amyloid formation.

This study uses RNA aptamers to detect pathological FUS in ALS, showing improved specificity and sensitivity compared to antibodies.

This study investigates how RNA affects alpha-synuclein phase separation, showing RNA induces morphological changes and promotes liquid-to-solid transition.

This paper designs aptamers targeting RAD51-BRCA2 interaction to inhibit RAD51 nuclear recruitment, enhancing DNA damage and cytotoxicity in pancreatic cancer cells.

This study uses an RNA aptamer to detect TDP-43 aggregation and shows that nuclear TDP-43 pathology and STMN-2 cryptic splicing occur before clinical symptoms in ALS.

The paper identifies host proteins interacting with SARS-CoV-2 RNA ends, highlighting pseudouridine synthase PUS7 and post-transcriptional modifications in viral RNA structure and function.

The paper analyzes the structural elements of the SARS-CoV-2 genome and predicts human protein interactions, identifying conserved regions and potential host factors involved in viral replication.