NeuroscienceCell ReportsPeer-reviewed
Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss
Tong Wu, Jian Zhu, Amy M. Strickland…·Jeffrey Milbrandt
This study identifies neurotoxins that activate SARM1 by binding to its allosteric site, leading to NAD+ depletion and neuronal death.
45 citations