Kwang Woo Ko

This study shows that paclitaxel induces cADPR production via Sarm1, increasing intra-axonal calcium and causing axon degeneration, with cADPR antagonists preventing neuropathy without affecting chemotherapy efficacy.

This study uses live imaging to show that SARM1 activation leads to a sequence of cellular events starting with ATP loss and ending in axonal self-destruction.

This study identifies neurotoxins that activate SARM1 by binding to its allosteric site, leading to NAD+ depletion and neuronal death.