PhysiologybioRxivPreprint
GDF3 is an endogenous antagonist of the ActE-ALK7/ACVR2 pathway in adipocytes
Nagasuryaprasad Kotikalapudi, Deepti Ramachandran, Evelyn Y Zhou…·Alexander S. Banks
This study identifies GDF3 as an endogenous inhibitor of the ActE-ALK7 pathway in adipocytes, showing its role in metabolic diseases like MASLD/MASH and suggesting GDF3 inhibition as a therapeutic target.