Mony J. de Leon

This study finds that hypertension is associated with reduced radiotracer removal from lateral ventricles, indicating impaired brain clearance.

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

The paper uses multi-compartment T2 relaxometry to show that parenchymal cerebrospinal fluid fraction increases quadratically with age in brain tissue.

This study uses diffusion MRI to find age-related white matter changes in canines, showing similarities to human aging patterns.

This paper develops a blood-based machine learning model to predict cerebral spinal fluid Aβ1-42 levels, showing high accuracy in identifying Alzheimer's disease risk.

The paper examines spatial relationships between white matter degeneration, amyloid load, and cortical volume in amnestic mild cognitive impairment and finds that WM degeneration correlates more strongly with cortical volume than amyloid.