Ileana Jelescu

Cortical organoid diffusion MRI reveals protocol-associated spatial reproducibility and increasing apparent diffusivity with diffusion time

This study uses cortical organoids to examine diffusion MRI reproducibility and apparent diffusivity changes with diffusion time, finding increased apparent mean diffusivity in most tissue voxels.

OCTOPUS: A versatile open-source tool creating realistic numericalbrain cells

OCTOPUS generates realistic digital brain cells with complex geometries to improve dMRI signal modeling and validate biophysical models.

The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales

This study evaluates microstructure-weighted connectomes using diffusion MRI data and finds that DePerp provides the most consistent structure-function coupling across spatial scales.

Comparative Systematic Analysis of Gray Matter BiophysicalModels on a Public Dataset

The paper compares four gray matter biophysical models on a public dataset, finding consistent parameter estimates and highlighting trade-offs in model complexity and robustness.

A Comprehensive Analysis Comparing Isotropic ADC to BOLD-fMRI: Sensitivity to Resting State Networks and Grey to White Matter Functional Connectivity

This study compares isotropic ADC-fMRI and BOLD-fMRI in detecting resting-state networks and grey-to-white matter connectivity, finding ADC more sensitive to structural grounding and functional coupling.

Introducing a translationally relevant mouse model of radiosurgery-induced unilateral hearing loss

This paper introduces a mouse model of radiosurgery-induced unilateral hearing loss and shows dose-dependent hearing loss and cochlear damage.

Characterising the diffusion functional signature of negative BOLD with interleaved TMS-fMRI in the human brain

The paper investigates negative BOLD responses using interleaved TMS-fMRI and dfMRI in the human brain, finding no ADC-fMRI response and suggesting sensitivity to subtle neural activity in ipsilateral regions.

Ultra-High Field 31P functional Magnetic Resonance Spectroscopy Reveals NAD+ Dynamics in Brain Energy Metabolism during Visual Stimulation.

This study uses 7T 31P fMRS to show NAD+ decreases during visual stimulation in the human occipital lobe, with no change in other metabolites.

Directed Brain Connectomics Revealed by Bicommunity Structure

This paper introduces directed connectomics using bicommunities to reveal asymmetric pathways in brain networks and validates them with electrophysiological data.

Validating Neurite EXchange Imaging (NEXI) using diffusion Monte Carlo simulations in realistic numerical gray matter substrates

This paper validates the NEXI model using diffusion Monte Carlo simulations in realistic gray matter substrates, showing it accurately recovers exchange times and disentangles exchange effects from microstructural features.

CATERPillar: A Flexible Framework for Generating White Matter Numerical Substrates with incorporated Glial Cells

CATERPillar generates realistic white matter numerical substrates with axons and glial cells, validated against histology and diffusion models.

Validating the Standard Model of diffusion MRI in white matter with Numerical Substrates

This study evaluates the Standard Model of diffusion MRI in white matter by testing it on realistic numerical substrates, revealing how model estimates change under various biological conditions and noise levels.

Microstructural correlates of white and gray matter in the healthy human brain: comparative analysis of diffusion biophysical models, inhomogeneous magnetization transfer, and macromolecular proton fraction

This study compares diffusion MRI and magnetization transfer metrics in healthy human brain tissue to understand their relationships with microstructural features like myelination and cell membrane properties.

Non-invasive prediction of conduction velocities in the human brain from MRI-derived microstructure features at 7 Tesla

This paper develops a whole-brain model to predict conduction velocity from MRI-derived microstructural features, explaining 29% of variance in neurophysiological conduction velocity.

Complementary BOLD- and ADC-fMRI explore the role of lateral superior colliculus in flicker fusion frequency

This study uses BOLD- and ADC-fMRI to investigate how the lateral superior colliculus contributes to the transition from static to dynamic vision in rats.

Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI

This study introduces isotropic ADC-fMRI to detect grey and white matter activity, showing it is more temporally specific than BOLD-fMRI and provides balanced mapping of both brain regions.

In-vivo characterization of magnetic inclusions in the subcortex from non-exponential transverse relaxation decay

This paper demonstrates non-exponential transverse relaxation decay in human subcortical grey matter using MRI, enabling characterization of magnetic inclusions with potential applications in Parkinson's disease.

Apparent Diffusion Coefficient fMRI shines light on white matter resting-state connectivity as compared to BOLD

This study compares BOLD and ADC-fMRI in functional connectivity, finding ADC-fMRI provides more robust white matter connectivity and higher inter-subject similarity.

Mapping activity and functional organisation of the motor and visual pathways using ADC-fMRI in the human brain

This study compares ADC-fMRI and BOLD-fMRI to show ADC-fMRI provides complementary insights into brain function by detecting neuromorphological activity in white matter and revealing functional organisation of visual pathways.

Evaluating the dependence of ADC-fMRI on haemodynamics inbreath-hold and resting-state conditions

This study evaluates ADC-fMRI's dependence on haemodynamics during breath-hold and resting-state conditions, finding it less affected by vascular contributions compared to dfMRI and BOLD.

Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents

The paper investigates MD and MK changes in rat brains during somatosensory stimulation, finding they reflect neural activity with higher sensitivity than BOLD.

Human gray matter microstructure mapped using Neurite Exchange Imaging (NEXI) on a clinical scanner

The paper estimates NEXI parameters in human cortex using a clinical MRI scanner and evaluates their repeatability and relationship to myelin water fraction.

Rebalance the inhibitory system in the elderly brain: Influence of balance learning on GABAergic inhibition and functional connectivity

This study shows that balance learning improves cortical GABA levels and functional connectivity in elderly adults, potentially counteracting age-related declines.

Activation mapping in multi-center rat sensory-evoked functional MRI datasets using a unified pipeline.

The paper assesses consistency of rat fMRI results across 12 centers using a unified pipeline and identifies variability due to experimental differences.

Subject classification and cross-time prediction based on functional connectivity and white matter microstructure features in a rat model of Alzheimer's using machine learning

The paper uses machine learning to classify and predict Alzheimer's progression in rats using MRI-derived functional connectivity and white matter features.

Beyond BOLD: Evidence for diffusion fMRI contrast in the human brain distinct from neurovascular response

This study demonstrates that diffusion fMRI (dfMRI) can detect brain activity contrasts distinct from BOLD, with specific activation maps and resting-state connectivity free from vascular artifacts.

Synchronous nonmonotonic changes in functional connectivity and white matter integrity in a rat model of sporadic Alzheimer's disease

This study shows nonmonotonic changes in brain connectivity and white matter in a rat Alzheimer's model, suggesting a compensatory mechanism that could be a therapeutic target.

Spatial relationships between white matter degeneration, amyloid load and cortical volume in amnestic mild cognitive impairment

The paper examines spatial relationships between white matter degeneration, amyloid load, and cortical volume in amnestic mild cognitive impairment and finds that WM degeneration correlates more strongly with cortical volume than amyloid.