Brian William Herrmann

This study compares the tonsillar microbiome of children with Down syndrome and obstructive sleep apnea to non-DS OSA patients, finding specific microbial shifts in DS tonsils.

This study identifies hyperactive interferon signaling and lymphoid tissue disorganization as drivers of adaptive immune dysfunction in Down syndrome across development and aging.

The paper measures intracochlear pressure during mastoidectomy to quantify noise exposure to the inner ear and finds levels exceeding 120 dBA, with a peak at 1.33 kHz.

The paper identifies DYRK1A triplication as the major cause of otitis media in Down syndrome by using mouse models and shows that normalizing its dosage restores the wild-type phenotype.