Andrew Parker

Synergistic interference with SARS-CoV-2 replication by Molnupiravir-derived N4 hydroxycytidine and inhibitors of CTP synthetase

This paper shows that combining N4-hydroxycytidine with CTP synthetase inhibitors strongly reduces SARS-CoV-2 replication in cell culture and animal models.

DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

The paper identifies DYRK1A triplication as the major cause of otitis media in Down syndrome by using mouse models and shows that normalizing its dosage restores the wild-type phenotype.

Using approximate Bayesian computation to quantify cell-cell adhesion parameters in a cell migratory process

This paper uses approximate Bayesian computation to assess cell-cell adhesion parameters in a wound-healing assay, showing that expanding experimental domain size improves parameter identification over increasing repeats.

Incorporating pushing in exclusion process models of cell migration

This paper introduces pushing mechanisms into exclusion process models of cell migration and evaluates their impact on population-level behavior.