Steve D. M. Brown

The paper identifies DYRK1A triplication as the major cause of otitis media in Down syndrome by using mouse models and shows that normalizing its dosage restores the wild-type phenotype.

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

This study investigates the role of Neuroplastin in mammalian hearing, showing that only the Np55 isoform is essential for cochlear hair cell function and that its absence interacts genetically with Cdh23 mutations to cause hearing loss.

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

LAMA automates 3D image analysis for mouse embryo phenotyping, integrating with an anatomical atlas to annotate dysmorphologies.

The paper introduces a method called soft windowing to improve analysis of high-throughput phenotyping data by reducing false positives and increasing significant results.