APOE2 promotes longevity independent of Alzheimer's disease
Mitsuru Shinohara, Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu, Jing Zhao, Xianlin Han, Patrick M. Sullivan, William G. Rebeck, John Denis Fryer, Michael G. Heckman, Guojun Bu
This study shows APOE2 is linked to longer lifespan regardless of Alzheimer's disease, with preserved activity and lipid metabolism playing a role.
bioRxiv · Aug 31, 2020 · PreprintNeuroscience