Guojun Bu

The paper identifies perivascular cells as phagocytes that clear CNS debris and shows Axl inhibition reduces pathology and improves recovery after spinal cord injury.

The paper identifies W2A-28, a dual modulator of class I HDACs and Wnt/β-catenin signaling, as a potential therapeutic for Alzheimer's disease.

The paper identifies epigenetic changes in Alzheimer's disease brains linked to tau pathology, highlighting oligodendrocyte gene perturbations as a potential common mechanism across tauopathies.

This study examines how APOE genotypes affect brain metabolome changes with aging in mice, finding that APOE2 genotype is associated with better mitochondrial function and BCAA utilization.

This paper introduces ProPPr, a method for proteomic profiling of phospho-tau aggregates in tauopathies, revealing common and disease-specific proteins associated with these lesions.

This study investigates changes in the UFMylation pathway in Alzheimer's disease brains, finding increased UFM1 conjugation and associations with pathological tau.

This study shows that the TREM2-H157Y mutation increases soluble TREM2 and reduces amyloid pathology in mice, suggesting a potential protective effect against Alzheimer's disease.

This study performs a genome-wide association study of brain biochemical phenotypes in Alzheimer's patients, identifying novel genetic loci and highlighting distinct genetic architectures for AD-related proteins.

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

This study identifies a novel interaction between TREM2 and TDP-43, showing TREM2 mediates microglial neuroprotection against TDP-43-related neurodegeneration.

This study shows APOE2 is linked to longer lifespan regardless of Alzheimer's disease, with preserved activity and lipid metabolism playing a role.