Yanyan Zhao

This study uses cryo-EM and deep learning to reveal the sequential structural changes in human TRiC during ATP-induced ring closure, showing asymmetric subunit responses and coordinated domain movements.

The paper visualizes the nucleation, condensation, and propagation of β-tubulin folding in the chaperonin TRiC, showing a hierarchical process involving nonnative structures and TRiC subunits.