Author

Andrew Glaser

Howard Hughes Medical InstituteORCID 0000-0003-2394-3047Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Adedolapo M. OjoawoiD· 2 shared Dorothee KerniD· 2 shared Camille SullivaniD· 1 shared Hannah K. Wayment-SteeleiD· 1 shared Logan A CalderoneiD· 1 shared R.A.P. PaduaiD· 1 shared Renee OtteniD· 1 shared Warintra PitsawongiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

Adedolapo M. OjoawoORCID

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2 papers

Recent·Most cited

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedJan 13, 2026

Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling

Andrew Glaser, R.A.P. Padua, Adedolapo M. Ojoawo…·Dorothee Kern

This study investigates how pathogenic mutations in SHP2's SH2 domains alter conformational dynamics, leading to hyperactivation by stabilizing a zipped β-sheet state.

4 citationstop 3%

humanstructural biology

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedOct 30, 2024

The conformational landscape of fold-switcher KaiB is tuned to the circadian rhythm timescale

Hannah K. Wayment-Steele, Renee Otten, Warintra Pitsawong…·Dorothee Kern

This paper characterizes the conformational landscape of KaiB, revealing its slow interconversion between states and how evolution tunes this process to match circadian rhythms.

22 citations

bacteria (other)structural biology

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