Adedolapo M. Ojoawo

Trained on missing NMR amide assignments in the Biological Magnetic Resonance Data Bank, Dyna-1 (ESM-3 layer 22 embeddings) predicts micro-to-millisecond conformational exchange seen in relaxation data.

This study investigates how pathogenic mutations in SHP2's SH2 domains alter conformational dynamics, leading to hyperactivation by stabilizing a zipped β-sheet state.

This paper characterizes the conformational landscape of KaiB, revealing its slow interconversion between states and how evolution tunes this process to match circadian rhythms.