Micah R. Hysong

The paper estimates whole-genome heritability of complex traits across diverse populations, finding rare and non-coding variants significantly contribute to heritability.

The paper examines how social determinants of health modify polygenic risk scores for cardiometabolic diseases and shows that integrating social and genetic factors improves disease prediction.

The paper integrates social risk factors with genetic risk scores to improve bipolar disorder prediction in the All of Us Research Program, finding social factors have larger effect sizes than genetic risk.

Admix-kit provides tools for genetic analysis of admixed populations, enabling simulation, association testing, and polygenic scoring.