Adebowale Adeyemo

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.

This paper develops and validates multi-ancestry polygenic risk scores for type 2 diabetes prediction and complications across diverse populations.

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

The paper identifies African-specific genetic loci associated with iron status and risk of severe malaria and bacteremia in children, highlighting limited transferability of European polygenic risk scores.

Pathway-Specific Polygenic Risk Scores for Blood Pressure Traits in a West African Cohort

The paper develops pathway-specific polygenic risk scores for hypertension in a West African cohort, finding improved predictive power compared to baseline models.

OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

Subcontinental Genetic Diversity in the All of Us Research Program: Implications for Biomedical Research

The paper analyzes genetic diversity in the All of Us Research Program, showing that self-identified race and ethnicity groups exhibit continuous genetic variation rather than discrete clusters, with implications for genetic association studies.

Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations

Admix-kit provides tools for genetic analysis of admixed populations, enabling simulation, association testing, and polygenic scoring.

Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications

This study identifies 1,289 genetic signals for type 2 diabetes in 2.5 million individuals, revealing distinct clusters linked to vascular complications and highlighting ancestry-specific genetic risk factors.

Epigenome-wide meta-analysis of BMI in nine population-based cohorts: examining the utility of methylation as a biomarker of BMI

This study identifies CpG sites associated with BMI and shows that epigenetic BMI prediction correlates with metabolic health markers.

Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

This study identifies 277 T2D loci using diverse populations and improves fine-mapping to assess causal genes and mechanisms, enhancing clinical translation.

GWAS in Africans identifies novel lipids loci and demonstrates heterogenous association within Africa

This paper conducts a GWAS in Africans to identify novel lipid loci and finds 23 novel associations, with some replicating in African Americans and additional loci emerging from meta-analysis.

Genetic Risk Scores for Cardiometabolic Traits in Sub-Saharan African Populations

This study evaluates genetic risk scores for cardiometabolic traits in sub-Saharan Africans, African Americans, and European Americans, finding significantly lower predictive utility in sub-Saharan Africans.

Polygenic Prediction of Type 2 Diabetes in Continental Africa

This study evaluates if African American or multi-ethnic polygenic risk scores improve type 2 diabetes prediction in continental Africans, finding that African American-derived scores are more predictive.

Implications of Genetic Distance to Reference and De Novo Genome Assembly for Clinical Genomics in Africans

This paper compares alignment-based and assembly-based variant calling in Africans, finding that assembly-based methods detect more clinically relevant variants and reveal biases in existing reference databases.

A Novel Type 2 Diabetes Locus in sub-Saharan Africans, ZRANB3, is Implicated in Beta Cell Proliferation

The paper identifies a novel type 2 diabetes locus, ZRANB3, in sub-Saharan Africans and shows its potential role in beta cell proliferation through zebrafish studies.