Author

Giuseppe Verdile

Curtin UniversityORCID 0000-0003-2475-0124Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

David GrothiD· 2 shared Mark AgostinoiD· 2 shared Melissa K. EcclesiD· 2 shared Amy WoodfieldiD· 1 shared Ayeisha Milligan ArmstrongiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersCell Biology

David GrothORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 15, 2024

Differential expression and modulation of presenilin-1 and presenilin-2 in neural cell lines

Melissa K. Eccles, Amy Woodfield, Ayeisha Milligan Armstrong…·Giuseppe Verdile

This study examines PS1 and PS2 expression differences in neural cell lines and shows PS2 ablation increases PS1 expression, highlighting their distinct roles in gamma-secretase activity.

DOI 10.1101/2024.10.15.618376

humanprotein sequence

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 17, 2023

Presenilin homologues influence substrate binding and processing by γ-secretase: a molecular simulation study.

Melissa K. Eccles, David Groth, Giuseppe Verdile, Mark Agostino

This study uses molecular simulations to compare substrate preferences between PS1 and PS2 γ-secretase enzymes for APP and Notch1 processing, revealing differences in conformational flexibility and binding energy.

DOI 10.1101/2023.05.17.541079

statistical model

𝕏 PostBluesky