Mark Agostino

This study investigates how designer PPR proteins bind to specific RNA sequences, showing they do not scan longer RNAs and instead rely on diffusion, with implications for their localization in organelles.

This study examines PS1 and PS2 expression differences in neural cell lines and shows PS2 ablation increases PS1 expression, highlighting their distinct roles in gamma-secretase activity.

This study shows EIF4A3 controls axonal tract formation by directly regulating microtubule dynamics in neurons, independent of its RNA-binding function.

This study uses molecular simulations to compare substrate preferences between PS1 and PS2 γ-secretase enzymes for APP and Notch1 processing, revealing differences in conformational flexibility and binding energy.