Cancer BiologyScience AdvancesPeer-reviewed
Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch
Kristjan H. Gretarsson, Stephen Abini-Agbomson, Susan L. Gloor…·Chao Lü
The paper identifies a critical binding interface in DNMT3A1 that facilitates DNA hypermethylation at Polycomb target genes by recognizing H2AK119Ub and the nucleosome acidic patch.
30 citations