BiochemistrybioRxivPreprint
Molecular basis of promiscuous chemokine-engagement by the Duffy antigen receptor
Manisankar Ganguly, Yuma Matsuzaki, Nabarun Roy…·Arun K. Shukla
This study determines the cryo-EM structures of DARC bound to chemokines CCL7 and CXCL8, revealing unique binding mechanisms and the role of tyrosine sulfation and allelic variation in chemokine engagement.
DOI 10.64898/2026.03.09.710718