Author

Hugh‐G. Patterton

Stellenbosch UniversityORCID 0000-0003-2550-0493Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:contrastive learning· 1 Research Focus:gene regulatory network inference· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Jessica Reid· 1 shared Leendert CloeteiD· 1 shared Mzwanele NguboiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

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3 top collaborators · 1 mutual co-author link

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1 shared paperMolecular Biology

Jessica Reid

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintAug 29, 2026

FuncSeek: Multi-PLM contrastive learning for protein functional similarity search

Leendert Cloete, Hugh‐G. Patterton

FuncSeek improves enzyme function prediction by using contrastive learning with multiple PLMs, outperforming existing methods on benchmark datasets.

DOI 10.64898/2026.08.07.738656

protein sequencecontrastive learning

𝕏 PostBluesky

Molecular BiologybioRxivPreprintDec 16, 2019

Structural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae

Mzwanele Ngubo, Jessica Reid, Hugh‐G. Patterton

The paper identifies four structural groups of histone H3 and H4 residues that regulate chronological lifespan in yeast, showing how specific substitutions affect lifespan through different mechanisms.

DOI 10.1101/2019.12.16.878983

yeaststatistical model

𝕏 PostBluesky