Author
Mzwanele Ngubo
Ottawa Hospital Research InstituteORCID 0000-0003-2715-5080Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2019-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 24 mutual co-author links4 papers
Recent·Most cited
- GenomicsbioRxivPreprint
A multiscale chromatin collapse underlies vascular pathology in Hutchinson -Gilford progeria syndrome
Mzwanele Ngubo, Naveen Ahuja, Rana Karimpour…·William L. Stanford
This study identifies chromatin reorganization and histone mark changes in HGPS VSMCs, linking them to vascular pathology through disrupted enhancer-promoter interactions.
- Molecular BiologybioRxivPreprint
HDAC2 inhibition restores H4K16ac and delays senescence in HGPS VSMCs
Rana Karimpour, Mzwanele Ngubo, William L. Stanford, Michael J. Hendzel
The paper identifies HDAC2 as the main regulator of H4K16ac in HGPS VSMCs and shows that its inhibition restores acetylation and delays senescence.
DOI 10.1101/2025.11.07.687234 - Molecular BiologybioRxivPreprint
Structural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae
Mzwanele Ngubo, Jessica Reid, Hugh‐G. Patterton
The paper identifies four structural groups of histone H3 and H4 residues that regulate chronological lifespan in yeast, showing how specific substitutions affect lifespan through different mechanisms.
DOI 10.1101/2019.12.16.878983