NeuroscienceCell Death and DiseasePeer-reviewed
ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS
Andrea Magrì, Cristiana Lucia Rita Lipari, Pierpaolo Risiglione…·Angela Anna Messina
The paper shows that TSPO overactivation, driven by ERK1/2 pathway activation, is linked to impaired mitophagy and reduced mitochondrial respiration in a mouse model of ALS.
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