Sophia Apostolidou

The paper uses methylation patterns in the protocadherin gene cluster to track clonal dynamics across human tissues over time, revealing subclonal architectures and cryptic expansions not detectable by standard mutation sequencing.

The paper tracks DNA methylation changes in blood samples up to 15 years before AML diagnosis, identifying DMRs linked to clonal expansions and epigenetic reprogramming.

This study uses serial blood samples to analyze pre-cancerous evolutionary dynamics in acute myeloid leukaemia, showing how driver mutations accumulate and drive clonal expansion over decades.