Author

Amanda B. Tan

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Adriana V.A. Fonseca· 2 shared Akemi D Ramos-Yamasaki· 2 shared Aleksandra Gentry‐MaharajiD· 2 shared Caroline J. WatsoniD· 2 shared Christopher T. BonifaceiD· 2 shared Jamie R. BlundelliD· 2 shared Lars L. P. HansseniD· 2 shared Sadik Esener· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Adriana V.A. Fonseca

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2 papers

Recent·Most cited

In vivo lineage tracing across human tissues using methylation barcodes in the protocadherin gene cluster

Samuel Hackett, Christopher T. Boniface, Adriana V.A. Fonseca, Akemi D Ramos-Yamasaki, Caroline J. Watson, Hannah M. L.* Bazin, Amanda B. Tan, Henson L. Lee Yu, Lars L. P. Hanssen, Harveer Dev, Sophia Apostolidou, Aleksandra Gentry‐Maharaj, Sadik Esener, Usha Menon, Jamie R. Blundell

The paper uses methylation patterns in the protocadherin gene cluster to track clonal dynamics across human tissues over time, revealing subclonal architectures and cryptic expansions not detectable by standard mutation sequencing.

bioRxiv · Feb 23, 2026 · PreprintGenomics

Methylation dynamics in the decades preceding acute myeloid leukaemia

Adriana V.A. Fonseca, Christopher T. Boniface, Caroline J. Watson, Samuel Hackett, Calum Gabbutt, Akemi D Ramos-Yamasaki, Amanda B. Tan, Jose Montoya, Ruslan Strogantsev, L. E. Hanssen, Y Q Zhang, Sophia Apostolidou, Aleksandra Gentry‐Maharaj, Sadik Esener, Paul T. Spellman, , Jamie R. Blundell

The paper tracks DNA methylation changes in blood samples up to 15 years before AML diagnosis, identifying DMRs linked to clonal expansions and epigenetic reprogramming.

bioRxiv · Jun 26, 2025 · PreprintGenomics