Author

Seth F. Vigneron

University of California, San FranciscoORCID 0000-0003-2671-3044Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biophysics· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

Brian K. ShoichetiD· 2 shared John J. IrwiniD· 2 shared Aashish ManglikiD· 1 shared Allan I. BasbaumiD· 1 shared Chase M. WebbiD· 1 shared Christian B. BillesbølleiD· 1 shared Dmytro S. RadchenkoiD· 1 shared Fangyu LiuiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Brian K. ShoichetORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJan 9, 2025

Docking 14 million virtual isoquinuclidines against the mu and kappa opioid receptors reveals dual antagonists-inverse agonists with reduced withdrawal effects

Seth F. Vigneron, Shohei Ohno, Joao M. Braz…·Brian K. Shoichet

The paper screens 14.6 million virtual isoquinuclidines against opioid receptors to identify dual antagonists-inverse agonists with reduced withdrawal effects compared to naloxone.

3 citations

mousestructural biology

𝕏 PostBluesky

BiophysicsNature Chemical BiologyPeer-reviewedJan 3, 2025

The impact of Library Size and Scale of Testing on Virtual Screening

Fangyu Liu, Olivier Mailhot, Isabella Glenn…·Brian K. Shoichet

This paper tests the impact of library size and testing scale on virtual screening by comparing results from 1.7 billion vs. 99 million molecule libraries against AmpC β-lactamase, finding improved hit rates and potency with larger libraries.

70 citationstop 1%

deep learningdrug response / drug discovery

𝕏 PostBluesky