Adam A Lauver

This paper presents a drug repurposing framework using in vivo transcriptomics to expand indications by matching drug signatures with disease signatures, successfully recovering established uses of semaglutide and proposing new ones.

This study compares immune cell composition and activation between hypertensive Bph/2 and normotensive Bpn/3 mice, finding differences in B and T cell subpopulations and reduced cytokine responses in Bph/2 mice.

This study shows that angiotensin II infusion increases T cell activation markers and specific cytokine responses in CD4 and CD8 T cells in mice.

The paper examines sex differences in cytokine production by T cells from hypertensive BPH/2 and normotensive BPN/3 mice, finding stronger cytokine responses in male BPN/3 mice compared to male BPH/2 mice, with fewer differences observed in females.

This study uses single nucleus RNA-sequencing to show that a high-fat hypertensive diet induces coordinated gene expression changes across cell types in thoracic perivascular adipose tissue in Dahl SS rats.