Stephanie Wengert Watts

In Vivo Transcriptomics-Based Framework for Systematic Indication Expansion

This paper presents a drug repurposing framework using in vivo transcriptomics to expand indications by matching drug signatures with disease signatures, successfully recovering established uses of semaglutide and proposing new ones.

A high-fat hypertensive diet induces a coordinated perturbation signature across cell types in thoracic perivascular adipose tissue

This study uses single nucleus RNA-sequencing to show that a high-fat hypertensive diet induces coordinated gene expression changes across cell types in thoracic perivascular adipose tissue in Dahl SS rats.

A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers

The paper uses snRNAseq to analyze thoracic aortic perivascular adipose tissue (taPVAT) and subscapular brown adipose tissue (BAT) in rats, identifying cell-specific gene expression and highlighting PIEZO1 as a key mechanotransducer in taPVAT.