Alexei Vázquez

The paper introduces a proteogeometric constraint that integrates cell geometry with proteome allocation in metabolic flux balance analysis.

The paper links cell growth rate to ribosome replication and macromolecular synthesis rates, showing how these constraints influence biomass composition in flux balance models.

The paper identifies compounds that mimic calorie restriction by inducing liver gene signatures similar to those observed under calorie restriction in mice and rats.

The paper investigates strategies to induce serine synthesis genes through dietary and pharmacological interventions, finding that low protein and ketogenic diets, as well as certain medications, increase their expression in the liver and brain.