Lin-Xing Chen

The paper identifies diverse phage-encoded proteins associated with bacterial cell envelope functions in huge phages, revealing potential roles in host interactions.

The paper designs active RNA-guided nucleases using AI and structure-guided methods, validated by cryo-EM and functional testing across species.

This study identifies amoC-encoding phages in freshwater lakes and shows their depth-structured infection patterns linked to ammonia-oxidizing bacteria.

The paper examines strain-level microbial overlap across river, groundwater, and hyporheic zone environments, finding limited establishment of transported strains despite connectivity.

The paper shows that phage-host predictions from MAGs are unreliable due to scaffold-level errors and proposes a validation framework to improve accuracy.

The paper identifies conjugative megaplasmids in the human gut microbiome that can disseminate prophage genomes across bacterial lineages, explaining their wide distribution.

The paper identifies megaplasmids in Enterobacteriaceae species, showing they are self-transmissible, encode drug resistance, and may enhance bacterial competitiveness.

The paper identifies Jug phages as prevalent in human and animal gut microbiomes, showing high transcription activity and potential ecological significance.

The paper curates a comprehensive database of huge phage genomes and protein structures, revealing a prevalent clade and unique protein folds with potential applications in microbiome research and biotechnology.

The paper reports the discovery of the largest known phage genome, BF3, and analyzes its protein-coding genes and structural predictions.

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

This study analyzes RNA virus diversity in wastewater treatment plants, identifying new viral lineages and their ecological and health implications.

The paper traces the evolutionary origin of eukaryotic RNA-guided endonucleases, showing they evolved from a specific clade of bacterial IS607 TnpB enzymes.

COBRA enhances viral genome assembly from metagenomes, producing high-quality genomes and revealing new phage species and circular genomes.