Mapping Structural Constraints and Adaptive Potential in a Capsule-Degrading Phage Tailspike Protein
Sarah Evert, Phil Huss, Dinesh Kumar Kuppa Baskaran, Karthik Anantharaman, Srivatsan Raman
This study uses deep mutational scanning to analyze a phage tailspike protein, revealing structural constraints and adaptive flexibility that influence its function and host range.
Science Advances · Sep 11, 2026Peer-reviewedBiochemistry