Michael W. Wolfe

This study identifies ESR2 as a regulator of Indian hedgehog signaling in neonatal rat ovaries, showing its role in controlling primordial follicle activation.

The paper identifies ERβ-regulated genes in granulosa cells that are essential for ovarian follicle maturation beyond the antral stage, revealing both known and novel genes involved in this process.

The paper investigates the role of ovarian KISS1 signaling in oocyte maturation and shows that ERβ regulates KISS1 expression in granulosa cells, which is essential for gonadotropin-induced oocyte maturation.

This study identifies SATB1-regulated genes in mouse ectoplacental cones and shows their role in trophoblast differentiation and placental development.

The paper identifies a long-range chromatin interaction that regulates Satb1 expression in trophoblast stem cells through ELF5 and SATB protein interactions.

This study shows that ESR2 prevents excessive activation of primordial follicles, and its disruption leads to premature ovarian senescence and reduced AMH and estradiol levels.