V. Praveen Chakravarthi

This study shows that Notch3 deletion reduces HIV-1 gene expression and systemic inflammation, improving outcomes in HIV-associated chronic kidney disease.

This study shows that DOT1L regulates TRPC6 expression in erythroid progenitor cells, affecting calcium influx and erythropoiesis.

This study identifies ESR2 as a regulator of Indian hedgehog signaling in neonatal rat ovaries, showing its role in controlling primordial follicle activation.

The paper identifies ERβ-regulated genes in granulosa cells that are essential for ovarian follicle maturation beyond the antral stage, revealing both known and novel genes involved in this process.

The paper investigates the role of ovarian KISS1 signaling in oocyte maturation and shows that ERβ regulates KISS1 expression in granulosa cells, which is essential for gonadotropin-induced oocyte maturation.

This study investigates the role of DOT1L in hematopoietic progenitor cells by analyzing transcriptomes of knockout and mutant models, revealing its function as a transcriptional repressor.

This study shows that DOT1L methyltransferase activity is essential for early murine hematopoiesis, as its loss causes embryonic lethality and genomic instability in hematopoietic progenitors.

This study identifies SATB1-regulated genes in mouse ectoplacental cones and shows their role in trophoblast differentiation and placental development.

The paper identifies a long-range chromatin interaction that regulates Satb1 expression in trophoblast stem cells through ELF5 and SATB protein interactions.

This study shows that ESR2 prevents excessive activation of primordial follicles, and its disruption leads to premature ovarian senescence and reduced AMH and estradiol levels.