Author

Shilong Gao

University of WashingtonORCID 0000-0003-2808-6283Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:deep learning· 1 Approach:diffusion model· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

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Aiko MuraishiiD· 1 shared Alex KangiD· 1 shared Asim Bera· 1 shared Avery Yang· 1 shared Beibei Zhao· 1 shared Davi Nakajima AniD· 1 shared David A. BakeriD· 1 shared Fanglei XueiD· 1 shared

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2026-2026 · peak 1/yr

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Aiko MuraishiORCID

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1 paper

Recent·Most cited

BioengineeringbioRxivPreprintOct 16, 2026

✦ In-depth digest

Complex enzyme active site scaffolding by iteratively detuned catalytic guidance

Tingli Qian, Weijin Wang, Shilong Gao…·David A. Baker

CaGE alternates guided structure prediction with sequence redesign, fading guidance each cycle, so sequences recover complex catalytic sites unaided; designed nonheme-iron and PLP-dependent enzymes were active.

1 citation

protein structureprotein sequence

𝕏 PostBluesky