Author

Cosimo Bruni

University of ZurichORCID 0000-0003-2813-2083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1

Frequent Co-Authors

Cristian IperiiD· 2 shared Muriel ElhaïiD· 2 shared Oliver DistleriD· 2 shared Alexandra A. KhmelevskayaiD· 1 shared Andrea LaimbacheriD· 1 shared Anna‐Maria Hoffmann‐VoldiD· 1 shared Anne CauvetiD· 1 shared Astrid HofmaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Cristian IperiORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 28, 2026

Compartmental Profiling of PDE4B in Systemic Sclerosis

Astrid Hofman, Pietro Bearzi, Sara Burckhardt…·Oliver Distler

This study characterizes PDE4B expression in systemic sclerosis (SSc) tissues, showing dysregulation in immune cells and protein enrichment in activated fibroblasts, supporting PDE4B as a therapeutic target.

DOI 10.64898/2026.07.27.740454

humanscRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJul 2, 2026

Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis

Celina Geiß, Camino Calvo-Cebrián, Miranda Houtman…·Muriel Elhaï

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

DOI 10.64898/2026.06.30.733140

humanscRNA-seq

𝕏 PostBluesky