Oliver Distler

Development of a multi-organ single-cell atlas of systemic sclerosis reveals shared and tissue-specific pathogenic pathways.

This study creates a multi-organ single-cell atlas of systemic sclerosis to identify shared and tissue-specific transcriptional programs and potential therapeutic targets.

Pulmonary pressure load shapes right ventricular molecular remodelling in dilated cardiomyopathy

This study identifies molecular changes in right ventricular tissue from DCM patients, showing that pulmonary pressure load drives transcriptional remodelling and fibrosis, while proteomic changes reflect immune activation and metabolic shifts.

Dysferlin is a novel regulator of COMP-positive matrifibrocytes in heart failure

This study identifies dysferlin as an antifibrotic regulator that limits fibroblast differentiation and myocardial fibrosis in heart failure.

Lanifibranor (IVA-337) - a pan-PPAR agonist suppresses TGF-β1-induced cardiac fibrosis and rescues cardiomyocyte function

This study shows lanifibranor reduces TGF-β1-induced cardiac fibrosis and improves cardiomyocyte function in human models.

The dual PPAR-α/δ agonist elafibranor attenuates TGF-β1-induced cardiac fibrosis through redox-metabolic and bioenergetic reprogramming in human cardiac models

This paper shows that elafibranor reduces TGF-β1-induced cardiac fibrosis by improving redox-metabolic and bioenergetic processes in human cardiac models.

Comparison of Culture Systems for Mouse Living Myocardial Slices in Cardiac Fibrosis Research

This study compares two culture systems for mouse living myocardial slices, finding the biomimetic system provides better viability, structure, and function for cardiac fibrosis research.

Compartmental Profiling of PDE4B in Systemic Sclerosis

This study characterizes PDE4B expression in systemic sclerosis (SSc) tissues, showing dysregulation in immune cells and protein enrichment in activated fibroblasts, supporting PDE4B as a therapeutic target.

Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

Metabolic-secretory decoupling defines a disease-intrinsic state in rheumatoid arthritis monocytes

The paper identifies a stable metabolic-secretory defect in RA monocytes across activation states using multi-omics analysis, linking reduced glycosylation to disease mechanisms.

Synovial fibroblast niche shapes the efficacy - safety dynamics of JAK inhibition in rheumatoid arthritis

This study identifies synovial fibroblasts as key targets of JAK inhibition in RA and reveals cytokine- and drug-driven mechanisms affecting JAKi efficacy and safety.

Distinct myeloid precursors and their interaction with mesenchymal cells orchestrate the spreading of psoriatic disease from the skin to the joints

The paper identifies a unique myeloid precursor population that facilitates the spread of psoriatic inflammation from skin to joints, interacting with fibroblasts to regulate T cell IL-17 expression.

5' HOXD Genes Differentially Regulate Gene Expression of Synovial Fibroblasts in Hand Joints

The paper shows that HOXD13 regulates gene expression in synovial fibroblasts, influencing primary cilia function and joint-specific RA pathology.

Radioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis

The paper uses radioproteomics to stratify molecular response to antifibrotic treatment in pulmonary fibrosis by analyzing radiomic and proteomic profiles in mice and patients.

A reference single-cell map of freshly dissociated human synovium in inflammatory arthritis with an optimized dissociation protocol for prospective synovial biopsy collection

The paper optimizes a dissociation protocol for fresh synovial biopsies and creates a single-cell reference map of human synovium in inflammatory arthritis, revealing new cell types and functions.