Author

Celina Geiß

University of ZurichORCID 0000-0002-8740-706XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Alexandra A. KhmelevskayaiD· 3 shared Caroline OspeltiD· 3 shared Marija LugariD· 3 shared Muriel ElhaïiD· 3 shared Raphael MicheroliiD· 3 shared Chantal PauliiD· 2 shared Christof SeileriD· 2 shared Cristian IperiiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Alexandra A. KhmelevskayaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of a multi-organ single-cell atlas of systemic sclerosis reveals shared and tissue-specific pathogenic pathways.

Cristian Iperi, Celina Geiß, Marija Lugar, Philip E. Stauffer, Nikolaos I. Vlachogiannis, Astrid Hofman, Alexandra A. Khmelevskaya, Petros Paul Sfikakis, Anna‐Maria Hoffmann‐Vold, Raphael Micheroli, Christof Seiler, Oliver Distler, Caroline Ospelt, Muriel Elhaï

This study creates a multi-organ single-cell atlas of systemic sclerosis to identify shared and tissue-specific transcriptional programs and potential therapeutic targets.

bioRxiv · Oct 31, 2026 · PreprintImmunology

Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis

Celina Geiß, Camino Calvo-Cebrián, Miranda Houtman, Ege Ezen, Katerina Apostolopoulou, Cristian Iperi, Melpomeni Toitou, Alexandra A. Khmelevskaya, Marija Lugar, Anne Cauvet, Yannis Djeffal, Mojca Frank‐Bertoncelj, Sam G. Edalat, Thomas Rauer, Katharina Zachariassen, , Muriel Elhaï

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

bioRxiv · Jul 2, 2026 · PreprintImmunology

Disease-specific fibroblast-myeloid interactions in rheumatoid arthritis synovium

Alexandra A. Khmelevskaya, Katerina Apostolopoulou, Camino Calvo Cebrian, Ege Ezen, Melpomeni Toitou, Phatthamon Laphanuwat, Masoumeh Mirrahimi, Celina Geiß, Marija Lugar, Asimina Kakale, Silja Malkewitz, Andrea Laimbacher, Dimitris Konstantopoulos, Vagelis E. Rinotas, Marietta Armaka, , Caroline Ospelt

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.

bioRxiv · Nov 17, 2025 · PreprintImmunology

decoupleR: Ensemble of computational methods to infer biological activities from omics data

Pau Badia-i-Mompel, Jesús Vélez Santiago, Jana M. Braunger, Celina Geiß, Daniel Dimitrov, Sophia Müller‐Dott, Petr Tauš, Aurélien J. F. Dugourd, Christian H. Holland, Ricardo O. Ramirez Flores, Julio Sáez-Rodríguez

decoupleR evaluates methods for inferring biological activities from omics data, finding simple linear models and consensus scores perform best in perturbation experiments.

Bioinformatics Advances · Jan 1, 2022Peer-reviewedBioinformatics