BiophysicsbioRxivPreprint
Compositional control of ageing kineticsin TDP-43 condensates
Nuria H. Espejo, Alejandro Feito, Ignacio Sanchez‐Burgos…·Jorge R. Espinosa
This study uses Molecular Dynamics simulations to show how different biomolecules affect the ageing kinetics of TDP-43 condensates, with arginine-rich peptides accelerating and poly-Uridine RNA slowing the formation of harmful cross-β-sheet structures.
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