Alejandro Castro

This study shows that cross-β-sheet nucleation, linked to ageing, preferentially occurs at biomolecular condensate interfaces due to a general physical mechanism, not specific protein sequences.

This study uses all-atom simulations to analyze nucleotide-nucleotide and nucleotide-amino acid interactions, revealing key binding modes and their role in biomolecular condensate formation.

The paper designs a computational pipeline to identify small peptides that slow condensate ageing in TDP-43 and FUS by reducing condensate density through electrostatic interactions.

This study uses Molecular Dynamics simulations to show how different biomolecules affect the ageing kinetics of TDP-43 condensates, with arginine-rich peptides accelerating and poly-Uridine RNA slowing the formation of harmful cross-β-sheet structures.