NeurosciencebioRxivPreprint
Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene
Judith Praena Fernandez, Annette Gärtner, Jesús Pérez‐Pérez…·Paolo Beuzer
The paper develops URSA, a method to quantify DNA repair activity at the CAG repeat tract in HD, showing it correlates with somatic instability and can be measured rapidly in blood cells.
DOI 10.64898/2026.07.29.741355