Author

Paolo Beuzer

CHDI Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Annette GärtneriD· 2 shared Ricardo Mouro PintoiD· 2 shared Thomas VogtiD· 2 shared A.L. Bergander· 1 shared Alexander Vogt· 1 shared Anastasia IllarionovaiD· 1 shared Anastasia KhvorovaiD· 1 shared Antje Cornelius· 1 shared

Activity by Year

2016-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Annette GärtnerORCID

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3 papers

Recent·Most cited

Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene

Judith Praena Fernandez, Annette Gärtner, Jesús Pérez‐Pérez, Sarah A. Cumming, Jia Feng, Katherine Van Belois, Kangning He, Denny Yang, Carla Castells-Esteve, Maria Bergé-Gardeñes, A.L. Bergander, Krzysztof P. Lubieniecki, Mihai Miclăuș, Nicolás Fissolo, Manuel Comabella, , Paolo Beuzer

The paper develops URSA, a method to quantify DNA repair activity at the CAG repeat tract in HD, showing it correlates with somatic instability and can be measured rapidly in blood cells.

bioRxiv · Jul 29, 2026 · PreprintNeuroscience

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding

Ella W. Mathews, Sydney R. Coffey, Annette Gärtner, Jillian Belgrad, Robert M. Bragg, Daniel O’Reilly, Jeffrey P. Cantle, Cassandra A. McHugh, Ashley Summers, Joachim Fentz, Tom Schwagarus, Antje Cornelius, Ioannis Lingos, Zoe N. Burch, Marina V. Kovalenko, , Jeffrey B. Carroll

This study investigates how different HTT-lowering therapies affect somatic instability in HD mice, finding that transcriptional repression and CAG repeat binding reduce SI without lowering HTT levels.

Nature Communications · Nov 14, 2025Peer-reviewedNeuroscience

Ex-STORM: Expansion Single Molecule Nanoscopy

Zhisong Tong, Paolo Beuzer, Qing Ye, Josh Axelrod, Zhenmin Hong, Hu Cang

This paper improves Expansion Microscopy to enable Ex-STORM, reducing fluorophore bleaching and preserving oxygen scavenging efficiency for better single molecule imaging.

bioRxiv · Apr 25, 2016 · PreprintBioengineering