The Fas-FADD-caspase-8 axis is a cancer cell-intrinsic determinant of cytotoxic lymphocyte-mediated killing
Elise Solli, Shixiong Wang, Qian Wei, Nathaniel Edward Bennett Saidu, Kjetil Taskén, Youxian Li
This study identifies the Fas-FADD-caspase-8 axis as a critical determinant of cancer cell susceptibility to cytotoxic lymphocyte killing, independent of executioner caspases.
bioRxiv · Jul 15, 2026 · PreprintImmunology