Michael D. Geschwind

This study identifies genetic variants associated with clinical duration in sporadic CJD but finds no significant SNPs for age at onset.

This study investigates the association between enlarged perivascular spaces (ePVS) and white matter injury, brain atrophy, cognitive decline, and inflammation markers in CADASIL, finding ePVS correlates with these pathologies and specific plasma proteins.

This paper quantifies the challenges of designing preventive clinical trials for genetic prion disease due to high variability in age of onset, suggesting the need for biomarker-based trials.

This study evaluates ELISA-based quantification of PrP in CSF as a biomarker for PrP-reducing therapeutics, showing its reliability and CNS origin.