Author

Nikolaos Karvelas

Icahn School of Medicine at Mount SinaiORCID 0000-0003-1452-1192Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Fanny M. ElahiiD· 4 shared Adam R. FergusoniD· 3 shared Bruce L. MilleriD· 3 shared Jonah N. KelleriD· 3 shared Anke Meyer‐Franke· 2 shared Hannah L. RadabaughiD· 2 shared Joel H. KrameriD· 2 shared Katerina AkassoglouiD· 2 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Fanny M. ElahiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 26, 2026

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

Zhaoqi Yan, Andrew S. Mendiola, Kelli Lauderdale…·Katerina Akassoglou

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 27, 2025

A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brain

Hannah L. Radabaugh, Jonah N. Keller, Caleb H. Radtke…·Fanny M. Elahi

The paper identifies a proteomic signature linked to vascular dysfunction and neurodegeneration in aging brains, highlighting thromboinflammation as an early pathway to tauopathy.

3 citations

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 28, 2024

Plasma Proteomics of Genetic Brain Arteriosclerosis and Dementia Syndrome Identifies Signatures of Fibrosis, Angiogenesis, and Metabolic Alterations

Jonah N. Keller, Hannah Radabaugh, Nikolaos Karvelas…·Fanny M. Elahi

The paper identifies plasma proteomic signatures associated with CADASIL stages, revealing fibrosis, angiogenesis, and metabolic alterations.

DOI 10.1101/2024.03.28.587249

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 17, 2023

Enlarged Perivascular Spaces are Associated with White Matter Injury, Brain Atrophy, Cognitive Decline and Markers of Inflammation in an Autosomal Dominant Vascular Neurodegenerative Disease (CADASIL)

Nikolaos Karvelas, Bradley C Oh, Earnest Wang…·Fanny M. Elahi

This study investigates the association between enlarged perivascular spaces (ePVS) and white matter injury, brain atrophy, cognitive decline, and inflammation markers in CADASIL, finding ePVS correlates with these pathologies and specific plasma proteins.

3 citations

humanproteomics

𝕏 PostBluesky